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Despite understanding the general picture of a solar cycle, it was rather difficult to match the observed sunspot numbers with the modeled ones unless the cycle is well progressed. This difficulty is a clear indication of some missing points in the definition of solar activity by sunspot numbers that turned our attention to the research of solar (poloidal) background magnetic field (SBMF) [1].
Different bioinformatic methods are already available to determine cancer ploidy and purity such as ABSOLUTE [50], ASCAT [51], THetA [52] and PyLOH [53]. The first two are however designed for SNP array data and do not formally model DNA sequencing data, THetA is designed to identify subclonal CNAs in mixed samples data obtained by high throughput sequencing (40X coverage) and is thus not suitable to low-pass sequencing data, PyLOH uses allelic information which is not available for low-pass sequencing data. 2ff7e9595c
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